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The Latest Science Behind Wrinkle Removal

Last Updated on by James Jackson

Wrinkles are a fact of life. Thankfully science is hard at work at wrinkle removal and/or wrinkle elimination. Let’s have a look at what science has discovered.

UBC & Granzyme B

University of British Columbia scientists have been looking at how to slow blood vessel deterioration and at the same time they may have come across the key to more youthful skin.

They were exploring the effects of Granzyme B, the protein-degrading enzyme, on blood vessels during heart attacks, when Professor David Granville noticed at the end of the experiment that mice engineered to lack the enzyme had beautiful skin while normal mice aged. This discovery took Granville in a new direction.

The researchers built a tanning salon for the rodents, where they exposed normal mice and the mice lacking the enzyme to UV light three times a week for a 20-week period where they were allowed to become red but not burn. When the experiment was over the engineered mice had smooth, unblemished skin and the normal mice had deep wrinkles.

A minimum of 80 percent of skin aging is the result of the sun, and when that gene is removed it protects against collagen loss and thus stops the formation of wrinkles. Many cosmetics for anti aging apply collagen to the skin, but this doesn’t stop the aging process.

Granville says that drugs that can block Granzyme B activity may be very valuable. Granville is the co founder of viDa Therapeutics, which is developing a lotion they hope will stop inflammation, sores, and facial scarring caused by sunlight.

University of Pennsylvania & Adipocytes

Normally fat cells, called adipocytes, are found in skin and they become lost as we age leading to permanent wrinkles. Scientists were able to harness bone morphogenetic protein, which was a signaling substance, found in wounds.

Recently University of Pennsylvania scientists, led by Professor George Cotsarelis, discovered a natural way to regenerate fatty cells that keep skin looking smooth and younger. This could lead to a new generation of anti-ageing treatments and the scar-free healing of wounds.

Gray hair, age spots, and wrinkles are all characteristics of aging creating a multi-million dollar cosmetic industry designed to keep them away. But the professionals say that in the future wrinkles may not be part of ageing. Scientists are able to instruct scar-forming cells to change into the adipocytes needed for healthy, younger skin.

The process was conducted in both mouse and human scar-forming tissue that was grown in the lab. While the research focused mostly on scarring, the implications are much wider. Their findings could result in new strategies to rejuvenate adipocytes in wrinkles, which could result in new anti aging treatments, and eventually injections or creams to treat wrinkles. This new silicon based “biomimetic film” tightens and protects the skin, while permitting it to breathe.

Dr. Terry James & Mirconeedling

Dr. Terry James, a dermatologist, founder of Beauty Bioscience calls microneedling the poor man’s laser. Traditionally, wounding the skin by dermabrasion, laser, or chemical peel was the only way to jump start the production of collagen causing rejuvenation and it can only be done occasionally, but microneedling has fewer limitations.

Dr. S. Tyler Hollmig, a Stanford assistant professor of dermatologic surgery, says that microneedling creates tiny micro-wounds that leave the epidermis intact while simultaneously triggering the body to fill them with collagen. You can repeat microneedling often, without producing the red irritated, skin that is seen with other treatments like a peel. It also has a lower risk of causing hyperpigmentation.

Beauty Bioscience did a study using microneedling, and it found that there was a 30% wrinkle reduction amongst women ages 41 to 64 when it was used for a couple of minutes three times a week, for 30-days.

Small studies found compelling evidence that microneedling works, although to date there has not been a lot of large, randomized control trials.


The latest non-invasive treatments like micro currents treat wrinkles and skin renewal. One clinical trial focused on determining how effective micro-current is in treating facial wrinkles. Participants were treated with micro current for 20-minutes on their faces 30 consecutive sessions. Which found micro current to significantly reduce wrinkles with patient satisfaction over 70%. The full study results can be found here!

Micro current is an electric current delivered at a rate of 1 microampere which equals 1 millionth of an ampere .They are harmless make blood circulate faster and lead to collagen stimulation. A number of studies have proven the benefits of micro currents using a stimulator current above 20 mille ampere to stimulate the muscles leading to the strengthening and firmness of damaged muscles.

HGH & Wrinkles

HGH or human growth hormone comes with research relating to not just wrinkles but aging in general. It would seem that as we age our body produces less HGH and as a result we start to show the signs of aging including wrinkled skin. By increasing our HGH production using an HGH supplement like Somatropinne or Genf20 Plus that helps the body to increase its production naturally, you can enjoy the many benefits of anti aging, including a reduction in wrinkles. Of course, it’s key that you choose a product that has the science behind it, as not all products are created equal.


The research continues to pour in about eliminating or at least decreasing wrinkles. For you this means options. What’s right for you?

1 Response to The Latest Science Behind Wrinkle Removal

  1. Jasmine Hewitt says:

    I have tried microneeding and it seems to work. but you can’t trust everyone online either. a ot of the devices sold are way too large for the face

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